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KMID : 0620920110430010007
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Experimental & Molecular Medicine
2011 Volume.43 No. 1 p.7 ~ p.14
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Microglial P2X7 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer’s disease
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Lee Hwan-Goo
Won Sun-Mi
Gwag Byoung-Joo
Lee Yong-Beom
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Abstract
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The possibility that P2X7 receptor (P2X7R) expression in microglia would mediate neuronal damage via reactive oxygen species (ROS) production was examined in the APPswe/PS1dE9 mouse model of Alzheimer’s disease (AD). P2X7R was predominantly expressed in CD11b-immunopositive microglia from 3 months of age before Aβ plaque formation. In addition, gp91phox, a catalytic subunit of NADPH oxidase, and ethidium fluorescence were detected in P2X7R-positive microglial cells of animals at 6 months of age, indicating that P2X7R-positive microglia could produce ROS. Postsynaptic density 95-positive dendrites showed significant damage in regions positive for P2X7R in the cerebral cortex of 6 month-old mice. Taken together, up-regulation of P2X7R activation and ROS production in microglia are parallel with Aβ increase and correlate with synaptotoxicity in AD.
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KEYWORD
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adenosine triphosphate, Alzheimer disease, amyloid β -protein precursor, Dlgh4 protein, mouse, microglia, reactive oxygen species, receptors, purinergic P2X7
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